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Evolution of human apolipoprotein E (APOE) isoforms: gene structure, protein function and interaction with dietary factors

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Fracture non-union often results in devastating outcomes for the patient and the surgeon [2, 5, 6], requiring a complex, long-lasting and expensive treatment, and a variable degree of morbidity is often a common finding [2, 7, 8]

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Pathogenic variants in CHEK2 are associated with an adverse prognosis in symptomatic early-onset breast cancer