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When initiating tirzepatide in patients also taking insulin or sulfonylureas, clinicians should consider reducing doses of these medications to mitigate hypoglycemia risk and monitor blood glucose closely

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Furthermore, structural comparison of two G q -coupled ghrelin receptors with the antagonist-bound ghrelin receptor (PDB: 6KO5) 18 supports the contention that these two complexes are indeed in the active state (Fig

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