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de la Cuesta-Zuluaga J, Mueller NT, Corrales-Agudelo V et al (2017) Metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut

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Initially a very tiny antibiotic dose is administered, and this is gradually increased over time (e.g., over a period of 6-12 hours)