The unexpected paradoxical worsening of psoriatic lesions after treatment with liraglutide was hypothesized to be due to cytokine imbalance with the release of IFN- and leukocyte chemotaxis after liraglutide-induced inhibition of TNF-, IL17, and IL23
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Most patients safely resume their GLP-1 regimen within 48 to 72 hours post-operatively, once they've tolerated clear liquids and solid foods without nausea
Stay hydrated aggressively
This is especially important considering the increasing use of these medications. The authors write that, to their knowledge, this is the first case detailing a patient developing this serious condition after starting tirzepatide for diabetes (in contrast to those treated with tirzepatide for weight loss)
