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The second law of thermodynamics applies to closed studbooks A basic tenet of physics is Rudolf Clausius' and Lord Kelvin's statement of the Second Law of Thermodynamics: "The amount of energy available for useful work in a given isolated system is decreasing

Numerous studies in recent years have shown that oxidative stress hypersensitivity plays a significant role in determining melanocyte degeneration, leading to the development of the disease [4]

intracellular activity persists hours longer due to nuclear gene-regulatory binding (per Khavinson et al.)

POLtheta processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

Therefore, any discussion of synergy is largely theoretical and based on extrapolation from individual studies

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