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Ultimately, it was revealed that cholinergic fibers are present within the subchondral bone of individuals with OA, and the release of acetylcholine (Ach) triggered by vagus nerve stimulation plays a prominent role in combating inflammation across various diseases while also providing pain relief

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Therefore, Trp metabolism is more appropriately understood as a key node linking immunometabolic states with the balance between immune tolerance and inflammation

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Analysis of calcium ion changes in aqueous humor in patients with senile cataract

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