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Premature graying is less normal

Cells were analyzed using a flow cytometer (FACS Aria, BD Biosciences) equipped with 488 nm laser for excitation

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Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression

In our previous study, pharmacokinetic and pharmacodynamic analyses ( n = 145) demonstrated that L-serine exhibited greater efficacy at higher doses, with regimens equivalent to 400 mg/kg/day leading to notable increases in K-VABS-II-ABC scores (1.73.7 points vs