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Transactivation of NRF2 in KO livers was further supported by constitutive induction of NRF2 target genes, including Gclc , metallothionein I ( Mt1 ) and heme-oxgenase 1 ( Hmox1) (Fig

2006;142C(2):77-85

Moreover, the more transient interactions of exendin-4 parallel the smaller effects of the mutagenesis on cAMP signalling for this peptide