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Excessive angiogenesis, as seen in conditions such as cerebral ischemia or BBB disruption, may benefit from targeted antiangiogenic interventions

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Theoretical concerns have been raised regarding cMet activation and potential tumour promotion, though shortduration studies have not observed neoplastic induction

239 Another phase II/III study evaluating ADI-PEG-20 for cisplatin and pemetrexed in patients with malignant pleural mesothelioma is ongoing and has completed recruitment (NCT02709512) (Table 1)

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