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doi:10.1074/jbc.271.24.14119

The Phase 2 trial showed that participants at 8mg achieved an average of 22.8% body weight reduction at 48 weeks

Common ingredients include methionine, inositol, choline, and sometimes B vitamins

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10.1038/s41420-025-02331-0 Cell Death Discov

These observations reinforce the need for well-designed randomised controlled trials (RCTs) to validate the findings and expand the evidence base