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AOD-9604 operates through the beta-3 adrenergic pathway independent of the IGF-1 axis and GHRH pathway, making it a clean independent variable alongside IGF-1 LR3 or GHRH analogues like CJC-1295 and tesamorelin in multi-compound research designs

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Sermorelin is a GHRH fragment that triggers pulsatile growth-hormone release from the pituitary with a modest IGF-1 rise