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Many related agents have played a role in preclinical animal experiments but rarely can be converted into clinical applications

Stress Biology 4(1):31 El-Yazied AA, Ibrahim MF, Ibrahim MA, Nasef IN, Al-Qahtani SM, Al-Harbi NA et al (2022) Melatonin mitigates drought-induced oxidative stress in potato plants through modulation of osmolytes, sugar metabolism, ABA homeostasis and antioxidant enzymes

In a study of obese men treated with the GLP-1 receptor agonist liraglutide, researchers observed improvements in testosterone levels along with metabolic health markers

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There are many milestone events for gut-liver-brain axis-related theory in the past few centuries