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Muscle Mass and Glucagon-Like Peptide-1 Receptor Agonists: Adaptive or Maladaptive Response to Weight Loss? Circulation, 2024

GSH-dependent activation releases Cu + to engage lipoylated DLAT and simultaneously unmasks glucose oxidase activity, inducing nutrient deprivation and triggering cuproptosis 216

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In clinical trials, patients lost around 22.5% of their body weight after 72 weeks of taking Mounjaro