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found that induction of haem oxygenase-1 through activation of the Nrf2-ARE pathway protected melanocytes from H 2 O-induced toxicity and that upregulation of Nrf2 expression reduced H 2 O 2 -induced apoptosis of human melanocytes [27]

Of interest, in the study design, the company states that included individuals had a flexible dosing protocol [125], which could have accounted for not meeting the desired 25% body weight reduction target