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See our Medicare GLP-1 coverage guide for the latest updates

Mithal says these numbers are only part of the story

The FDA shortage designation for tirzepatide has been continuous since December 2022 not because Eli Lilly can't manufacture enough, but because demand at $1,400 monthly far exceeds what insured populations alone represent

Choosing Between Ozempic and Mounjaro The choice between Ozempic and Mounjaro will depend on various factors, including: Efficacy Needs: For those requiring a significant reduction in HbA1c and weight loss, Mounjaro may be the preferred option

For patients who cannot tolerate GLP-1 side effects, who have already lost weight with GLP-1 therapy and want to sustain metabolic health, or whose primary issue is insulin resistance and visceral fat rather than caloric surplus, MOTS-c addresses a different problem

A 2025 Stanford Medicine study identifying a naturally occurring peptide that suppressed appetite and reduced body weight without the nausea and muscle loss associated with semaglutide confirmed what many clinicians had already observed: the GLP-1 mechanism is powerful, but it carries side effects tied directly to how it works