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As these medications become more widely used, it will be important to monitor their long-term safety, tolerability, and how well patients stick with the treatment in real-world settings

In one report, three patients with dumping syndrome and refractory hypoglycaemia had insufficient benefit of the reversal of their gastric bypass and they ultimately required partial pancreatectomy for control of neuroglycopenia 117

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Finally, the question of Se efflux from the brain is not properly addressed

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The majority of published research on peptide therapies has been conducted in preclinical (animal) models