(PNG) S2 Fig
Circulating adiponectin levels do not always decrease uniformly in obesity models and may remain unchanged or show compensatory responses depending on disease duration and metabolic context 39,40
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It is released after eating and plays a critical role in regulating: Blood sugar levels Insulin secretion Appetite signaling Digestion speed Inflammatory responses GLP-1 communicates directly with the brain, pancreas, heart, and immune system, making it far more than just an "appetite hormone." When GLP-1 binds to its receptors, it helps the body respond to food more efficiently and maintain metabolic balance
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