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September 19, 2025 10:48 View More Beyond the Hype The Truth About GLP-1s, Weight Loss & Healing with Melissa Afflerbach In this special in-person episode of the Modern Thyroid and Wellness podcast, host McCall McPherson is joined by Melissa Afflerbach, Program Director at Modern Weight Loss, for a candid and empowering discussion about GLP-1 medications like semaglutide and their evolving role in weight loss and metabolic health
When administered therapeutically, GLP-1 receptor agonists work through several mechanisms: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner [1] [4] Suppressing glucagon release from alpha cells, reducing hepatic glucose output Slowing gastric emptying , which helps moderate post-meal blood glucose rises Promoting satiety through central nervous system pathways, potentially supporting weight reduction Investigational transdermal GLP-1 delivery systems typically utilise specialised technologies such as microneedles or active delivery methods rather than conventional patches, as GLP-1 molecules are large peptides that do not easily penetrate the skin barrier
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PMID: 18577568
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