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Where neuroinflammation can be either promoted or restricted by astrocytes through release of pro-inflammatory or anti-inflammatory molecules, leukocyte recruitment and forming functional barriers for CNS parenchyma (Sofroniew, 2015)

That will require larger, dedicated randomized trials in addiction, targeted studies in pain syndromes beyond knee osteoarthritis, longer-term musculoskeletal safety data, and honest communication about both the promise and the risks of GLP-1s

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this procedure can be expensive and challenging to transfer from laboratory-scale grafting to commercial production owing to its complexity (Klicova et al., 2023

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