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Historically, glucagon was viewed solely as a hyperglycemic hormone

Moreover, expression levels of neuronal differentiation 1 ( NEUROD1 ), which is a transcription factor with a critical role in cell fate and maturation (47), follow similar patterns to the aforementioned genes, with the highest expression in the -4 subcluster (Figure 3D)

Dysbiosis can affect the kynurenine pathway of tryptophan metabolism, leading to an imbalance in neuroactive metabolites that influence mood, cognition, and pain perception (He et al., 2023)

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In submaximal cycling, the use of oxygen (VO) was also lower with the real beet ingestion

The polar metabolite clusters displayed more significant mean differences between the highest (Q4) and lowest (Q1) quartiles, as shown in Supplementary Tables 5,6