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Inject subcutaneously or intramuscularly

The timeframe for noticing an improvement can vary from person to person

In the SURMOUNT-1 trial, tirzepatide produced average weight loss of 15-22.5% of body weight over 72 weeks depending on dose

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Situations where oral administration is not feasible (e.g., anorexia, nausea, pre-op, GI absorption issues)

Some ambitious protocols run all three, but that level of complexity is best reserved for experienced users who have already run each compound individually and understand their response