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Zu ZY, Jiang MD, Xu PP, et al
demonstrated that pharmacological approaches targeting anabolic pathways can shift body composition toward fat loss while preserving or gaining muscle in adults with obesity ( JAMA Network Open , 2021)
Plasma SPARC levels positively correlate with lumbar spine BMD, and 12 months of recombinant human parathyroid hormone (134) treatment in osteoporotic patients increases the circulating SPARC level, which is associated with changes in lumbar BMD at L2-L4 [24]
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In the absence of GSH synthesis, FoB upregulate mTORC1 and reprogram their metabolism towards glycolysis, which is similar to the metabolic program of wild-type MZB
