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The short answer is: it depends on what symptoms you have and how deficient you are

Research has found that vitamin B12 provides weight loss to those who increase their intake

The glucose-lowering effect proved so robust that tirzepatide earned FDA approval for type 2 diabetes management before its weight loss indication

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NAD and energy metabolism : Shown to increase intracellular NAD levels by up to 1.6-fold, supporting mitochondrial function and cellular energy production

PMCID: PMC4953733