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Approximately 25% of total weight lost on tirzepatide was lean mass (SURMOUNT-1 DXA substudy), and in semaglutide trials, that proportion may reach up to 40% (STEP 1 DXA subset)

Although MRI findings may alert clinicians to a possible MMNST lesion, a definitive diagnosis of MMNST can only be made through a combination of histopathological and immunohistochemical profiling because of the many overlapping features with other melanocytic and nerve sheath tumors

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