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We found that many human hypothalamic neurons expressed GLP1R mRNA and were significantly activated by GLP-1 and other GLP-1R agonists including exendin-4 derivatives, liraglutide, semaglutide, and the dual GLP-1R/GIPR agonist tirzepatide (a.k.a

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By improving glucose-dependent insulin secretion, slowing gastric emptying, and reducing appetite, it can significantly influence blood sugar regulation and body weightdriving widespread interest in medical weight management (2)