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Follistatin-344 sequesters myostatin extracellularly before ActRIIB engagement: 1:2 follistatin:myostatin stoichiometry (two myostatin monomers cradled per follistatin molecule)

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Taken together, GCGR agonism offers a promising yet complex strategy in cardiometabolic disease, as it promotes weight loss and energy expenditure while also increasing blood glucose, underscoring the need for dual- and triple-agonist approaches (GLP1R/GIPR/GCGR) that balance metabolic and CV effects

The relative reductions in obesity rates are projected to be highest at younger ages, where uptake for the medications is expected to be higher

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After initiation, follow-up scans are typically recommended every 3 to 6 months to monitor changes in fat and muscle mass