Isothiocyanates may sensitize cancer cells to anticancer drugs and/or increase drug cytotoxicity, as shown in in vitro and animal models
Could GLP-1 agonists be the answer they are looking for
Experiments using purified human VDAC2 reconstituted into artificial liposomes confirm that erastin can bind this target and modulate transport flux [27]
Dispensing now at Felix
TLDR: "Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to obesity." Key findings: After stopping liraglutide, patients regained ~2.2 kg After stopping semaglutide/tirzepatide, patients regained ~9.7 kg Weight regain was proportional to initial weight loss Lifestyle changes alone DID NOT prevent regain Implication: GLP-1 receptor agonists are not a short-term solution
Lorente L, Martn MM, Gonzlez-Rivero AF, Prez-Cejas A, Abreu-Gonzlez P, Ramos L, Argueso M, Cceres JJ, Sol-Violn J, Alvarez-Castillo A, Jimnez A, Garca-Marn V