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Between the pharmacological options, the GLP-1RA, originally approved for the treatment of DM2, have been demonstrated to be useful for body weight reduction in obese individuals

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Type 2 Diabetes / Prediabetes Originally developed as a diabetes medication (HbA1c reduction of ~2.1%)

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SGLT-2s and GLP-1s are costly, but lower cost options (like sulfonylureas) were inferior in reducing all-cause mortality and morbidity, the ACP stated