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in Cell Metabolism , increased NAD availability stimulates PGC-1 through SIRT1 activation, leading to enhanced mitochondrial function and improved metabolic flexibility (Cant et al., Cell Metabolism )

Although BDNF knockdown in the dDG induced several behavioral deficits, injection of LV-shBDNF into the CA3 did not induce any behavioral alterations as measured using the same battery of tests (Figure 3)

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