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Caspase-mediated ablation of ARC GLP-1Rexpressing neurons did not block semaglutide-induced weight loss (123), and CRISPR-mediated GLP-1R knockout in the ARC did not affect acute liraglutide-induced anorexia (125)
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It was reported that the aberrant phosphorylation of tau protein leads to a series of events that can result in neuronal cell death
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Nature 330 , 163165 (1987)
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