Journal of Diabetes Research, 15(2), 123-135
Obesity : Independent of medication effects, obesity itself confers increased pancreatitis risk and may complicate diagnosis due to body habitus
The use of an anti-human GIPR antibody (hGIPR-Ab) replicated these results in obese non-human primates (NHPs), with an even more pronounced weight loss observed than in mice
Importantly, FIH studies also provide essential information for the design of Phase 2 trials , including decisions related to dosing schedules, administration frequency and safety monitoring strategies
Fiber Supplements: If dietary intake is insufficient, a psyllium-based fiber supplement (e.g., Metamucil) can be helpful
doi:10.5603/CJ.a2022.0068 Surma S, Oparil S