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Excessive ROS accumulation damages cellular components, including proteins, lipids, and DNA, exacerbating mitochondrial dysfunction and potentially initiating a cascade of neurodegenerative processes

PMID: 23162786

And Johnson himself has admitted to having blind spots in the past

[2] Several postmarketing reports of pancreatitis (some fatal) have been made in people treated with sitagliptin and other DPP-4 inhibitors, [23] [24] and the US FDA package insert carries a warning to this effect, [2] although the causal link between sitagliptin and pancreatitis has not yet been fully substantiated

Liang Q, Mohan RR, Chen L, Wilson SE (1998)

Nishikiori N, Ohguro H, Watanabe M, Higashide M, Ogawa T, Furuhashi M, et al