glp-1 and ms The Role of Glucagon-Like Peptide-1 Agonists in the Treatment of Multiple Sclerosis: A Narrative Review Five Key Advantages of the

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Safety Comparison# Key Differences Summary# Weight loss : Comparable (~20-21%), no head-to-head trial Mechanism : Amylin/GLP-1 (CagriSema) vs GIP/GLP-1 (tirzepatide) Molecules : Two-peptide combination vs single dual-agonist molecule Approval : Tirzepatide is FDA-approved

The SURMOUNT-1 trial showed participants losing up to 22.5% of their body weight on the highest dose, compared to approximately 15-17% with semaglutide in the STEP trials

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