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ICP34.5 disrupts retinoic-acid-inducible gene I (RIG-I) signaling preventing interaction between RIG-I and mitochondrial antiviral signaling protein (MAVS), a pivotal adaptor inhibiting downstream activation IRF3 and subsequent IFN production (33)

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Following analyzing the molecular dynamics trajectories and evaluating the dynamic shifts of DPP-4 after its molecular interactions with the designed compounds via dynamic cross-correlation matrix, free energy landscape and MM-PBSA calculations, all data show that the proposed DPP-4 inhibitors create extremely stable complexes when compared to the clinical DPP-4 inhibitor (alogliptin)

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