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Thyroid function changes during prolonged caloric restriction contribute to slowed metabolism

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The cardiometabolic improvements seen during semaglutide treatment reverted towards the baseline in our study, similar to the findings in the STEP 1 study ( When interpreting the endocrine and cardiometabolic outcomes, it is important to highlight that participants in our cohort were already treated with metformin before the semaglutide intervention, therefore prior the baseline assessment