Definition and Overview GLP-1 agonists are synthetic compounds designed to activate the GLP-1 receptors in the body, mimicking the actions of the endogenous GLP-1 hormone
When GLP-1 binds to GLP-1R, it: Stimulates insulin secretion in the pancreas to regulate blood glucose levels
Macrophage polarization in pathology
In vitro experiments using STC-1 cells as enteroendocrine cells demonstrated that ICG-001, a selective inhibitor of Wnt/catenin signaling, dose-dependently reduced proglucagon gene expression
Researchers found that the tongue biopsies showed increased activity of genes associated with taste signaling transduction pathways, neural plasticity, and renewal of taste buds in the tongue, in those who took semaglutide
References: A Brave New World: Therapeutic Area Deep Dives on Obesity This blog is part of a new series exploring a range of topics in the obesity market, including: market size and scope, impact of payer controls, activity in non-traditional channels, patient behavior, GLP-1 impact, HCP responses, the policy landscape, pharmacy economics, and the outlook for the future of GLP-1
