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First, although HG exposure is widely recognized in the literature as a common in vitro model to mimic diabetes-induced cellular damage, it does not fully replicate the complexity of the DR

There are many mast cells near the BBB

Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to Metformin in subjects with type 2 diabetes

A network meta-analysis of 22 RCTs covering 2,258 participants found GLP-1 receptor agonists reduced lean mass by a mean of 0.86 kg, with lean mass comprising roughly 25% of total weight lost across agents