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Benefits of probiotic supplementation were reported in animal models of arthritis and human studies, but the current evidence regarding the effect of probiotic supplementation in the management of RA remains insufficient to make definite recommendations
Subsequent Gene Ontology (GO) enrichment analysis delineated marked perturbations in key biological processes, including cellular processes (e.g., membrane integrity maintenance), metabolic reprogramming (particularly carbohydrate and lipid metabolism), cellular anatomical entity organization (notably gut epithelial junction complexes), catalytic activity modulation (encompassing oxidoreductases and hydrolases), and molecular binding dynamics (e.g., receptor-ligand interactions) (Figure 2G)
Its capacity to improve core symptoms, combined with modulating gut microbiota, makes it a promising candidate for mechanism-based intervention
There are also topical forms like creams or gels that can be applied directly to the skin to relieve itching from bug bites or rashes
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