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This is the most specific neurological symptom of B12 deficiency

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Reports of heavy fatigue and flu-like symptoms cluster among users who moved from maximum-dose tirzepatide directly to 4 mg or more of retatrutide

Baulande, S., Lasnier, F., Lucas, M

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However, some individuals report experiences that suggest possible associations between B12 and anxiety-like symptoms in certain contexts: High-dose supplementation : Some individuals report feeling 'overstimulated' or experiencing changes in energy levels when initiating B12 supplements