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Dena Dubals lab at UCSF (Cell Reports, 2017) showed that peripheral klotho fragment administration enhanced cognition and neural resilience in young, aging, and -synuclein transgenic mice through NMDA receptor-dependent mechanisms

(4) Miriam Granado, Cristina Garca-Cceres, Laura M Frago, Jess Argente, and Julie A Chowen (2010) The positive effects of growth hormone-releasing peptide-6 on weight gain and fat mass accrual depend on the insulin/glucose status Endocrinology, 2010 May, Volume 151 (Issue 5), Pages 2008-18

Nausea, bloating, and constipation make GLP-1 nearly unbearable for 40% of users

Lotte Bjerre Knudsen , a researcher at Novo Nordisk , took this discovery further