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As only one patient with IIH-WOP was treated with a GLP-1-RA, this was insufficient to conduct subgroup analyses, so we could only perform sensitivity analyses removing IIH-WOP patients to exclude potential confounding effect on our results

Leptin interacts with satiety circuits in feeding centers in the ventromedial and lateral hypothalamus (183), whose importance is demonstrated by the severely obese phenotypes of human subjects when target genes are disrupted (184)

It is the subject of ongoing experimental and preclinical research investigating its chemical properties, receptor interactions, and role in neuronal signalling pathways

Semgo works by mimicking a natural hormone, GLP-1, which helps regulate blood sugar levels, promotes insulin production, and reduces appetite, thereby supporting weight loss