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Note: Always consult with a licensed healthcare provider if you suspect your medication has been compromised or if you have questions about your specific dosing schedule

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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 15% by weight of the poloxamer

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Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group

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