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Intraduodenal delivery of a bolus of dextrin and a bolus of Liposyn (20%) in rats each induce 800 and 400 pg/mL peaks, respectively, in lymph GIP concentrations at 60 min (Lu et al., 2008)

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12 (4), e820

Common challenges target: composition claim scope (sequence variants, analogs, and pegylated or acylated differences), method-of-treatment claims (carve-outs around dosing regimens, endpoints, or indication), formulation and device (stability systems, delivery mechanics, and concentration/vehicle definitions), manufacturing process (where competitors alter cell lines or purification steps to avoid manufacturing claim coverage)

Cell population distributions in G0/G1, S, G2/M and apoptotic phase of the cell cycle were analyzed with FACSDiva (BD Biosciences) and FlowLogic (Miltenyi Biotech) softwares

The loading phase requires 4mg to 5mg weekly for the first month, which represents a meaningful investment