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Disruption of iron homeostasis not only triggers intracellular oxidative stress but also activates both central and peripheral immune responses, establishing a ironimmunity-neurodegeneration feedback loop that amplifies inflammation and exacerbates neuronal damage

Oral doses of 0.55mg are most common in published research, but 4060% first-pass metabolism means actual CNS exposure is significantly lower than nominal dose

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The NSBSO consists of a hydrophobic self-assembled peptide motif and a hydrophilic peptide derivative containing BSO that inhibits the synthesis of GSH

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