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Appelman, Charlton (141) showed that skeletal muscle structure is associated with a lower exercise capacity in LC patients, and local and systemic metabolic disturbances, severe exercise-induced myopathy, and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with LC worsen after induction of post-exertional malaise (141)

Sender, R., Fuchs, S

Age-related cognitive decline may be associated with reduced oxytocin levels, as this hormone influences multiple areas of the brain and could be a critical element that diminishes with age

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Evidences supporting this theory started to rise in the middle of the 20th century (Zubrod et al., 1951

Front Physiol (2017) 8:350