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Taking into account that reactive astrocytes may produce various neurotrophic factors and antioxidant molecules targeting neuronal survival, it is possible that genetic manipulation of these functions in astrocytes may represent a promising strategy to improve dopaminergic neurons or neural progenitor cells survival [4,23]

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In vitro, apigenin inhibited -hexosaminidase and histamine release in a noncytotoxic manner [134]

Preparing PT-141 nasal spray involves higher concentration reconstitution (10mg/ml or 20mg/ml rather than standard 5mg/ml for injection) to minimize liquid volume per dose, using empty nasal spray bottles with metered pumps delivering 0.1ml per spray, and calculating doses accounting for reduced bioavailability

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