Methionine sulfoxide can be subsequently reduced back to methionine by specific reductases, thereby restoring A1ATs functionality and enabling continuous ROS scavenging ( Beside the described scavenging effect, however, oxidation of methionine residues leads to a decrease in the protective effect of A1AT as a protease inhibitor ( For this reason, an increasing number of studies reports the development of engineered forms of A1AT, with amino acid substitution at methionine 351 and 358, designed to keep the anti-protease activity, even in a oxidative microenvironment ( Additionally, the cysteine residues in A1AT may undergo oxidation, which decreases ROS levels
Phytoestrogens and Neurogenesis Phytoestrogens have been previously described by their ability to promote the differentiation of diverse types of stem cells, including NSPCs (Heim et al., 2004
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Diabetes, 59 (8), 18991905
p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinsons disease
G.PollerB.WagenaarE.BeijnenJ