We know that one of the key factors influencing the microbiome is diet, says Esser
GI symptoms from retatrutide introduction are expected and should be managed with dietary adjustments, smaller meals, and adequate hydration
Majority of the present GLP-1 based studies employ GLP-1 analogs such as exenatide as their primary drugs, which raises a question for their cardiovascular safety and contribution to major adverse cardiovascular events (MACE)
Ozempic, however, is also approved for reducing cardiovascular risks in people with Type 2 diabetes who have established cardiovascular disease
Studies were divided between pre-clinical and mechanistic evidence, and clinical evidence
Inability to maintain adequate oral fluid intake due to these symptoms constitutes a medical concern requiring provider contact