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Creatine supplementation seems to improve cognitive performance and brain function while reducing mental fatigue, particularly in stressful times

One early study is often cited to show a lack of absorption

Through analysis of fecal samples and functional magnetic resonance imaging data from 23 MDD patients, the study determined that the relative abundance of fecal Bacteroides was significantly negatively correlated with functional connectivity in depression-related brain regions ( r = 0.67, P = 0.0005)

Nutraceuticals or dietary supplements have also proven to be effective tools in treating pathological conditions like obesity as they harbor high levels of bioactive compounds that confer health benefits

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