Three studies investigated the effect of liraglutide, an approved GLP-1 agonist for the treatment of obesity
4 In the natural, healthy state, Central GIP signals decrease food intake and overcome the weight-promoting effects of physiologic GIP levels in adipose tissues
28 In people without diabetes but with obesity and pre-existing cardiovascular disease, 2.4 mg semaglutide once weekly was shown to reduce the risk of a composite of death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke by 20% over a median of 3.25 years

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doi: 10.7759/cureus.56737 28 FrhlichE.WahlR
Be sure to hold the injection pen or syringe tight in your hand